Evaluation of oxidative stress markers and cardiovascular risk factors in Fabry Disease patients

Genetics and Molecular Biology

Karen B. Müller¹  Luciano C. Galdieri¹  Vanessa G. Pereira¹  Ana M. Martins¹  Vânia D'almeida¹ 

[1] ,Universidade Federal de São Paulo Departamento de Pediatria São Paulo,Brazil

关键词: inborn errors of metabolism;    Fabry Disease;    homocysteine;    oxidative stress;   

DOI  :  10.1590/S1415-47572012005000031

来源: SciELO

【 摘 要 】

Fabry Disease, an X-linked inborn error of metabolism, is characterized by progressive renal insufficiency, with cardio and cerebrovascular involvement. Homocysteine (Hcy) is considered a risk factor for vascular diseases, but the mechanisms by which it produces cardiovascular damage are still poorly understood. Regarding the vascular involvement in FD patients, the analysis of factors related to thromboembolic events could be useful to improving our understanding of the disease. The aim of this study was to evaluate plasma Hcy and other parameters involved in the methionine cycle, as well as oxidative stress markers. The sample consisted of a group of 10 male FD patients and a control group of 8 healthy individuals, paired by age. Venous blood was collected for Hcy determination, molecular analysis, identification of thiobarbituric acid reactive substances, total glutathione and antioxidant enzymes activity, as well as vitamins quantification. Comparative analysis of FD patients versus the control group indicated hyperhomocysteinemia in 8 of the 10 FD patients, as well as a significant increase in overall glutathione levels and catalase activity. It is inferred that FD patients, apart from activation of the antioxidant system, present increased levels of plasma Hcy, although this is probably unrelated to common alterations in the methionine cycle.

【 授权许可】

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