Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease

Genetics and Molecular Biology

Vanessa L.n. Dalepiane²  Daiane N. Silvello¹  Crislaine A. Paludo¹  Israel Roisenberg¹  Daniel Simon² 

[1] ,Universidade Luterana do Brasil Programa de Pós-Graduação em Diagnóstico Genético e Molecular Canoas RS ,Brazil

关键词: atherosclerosis;    coronary artery disease;    gene polymorphisms;    matrix metalloproteinases;   

DOI  :  10.1590/S1415-47572007000400001

来源: SciELO

【 摘 要 】

Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). In this study we tested the hypothesis that polymorphic variation in the MMP genes influences the risk of developing atherosclerosis. We analyzed functional polymorphisms in the promoter of the MMP-1, MMP-3, MMP-9 and MMP-12 genes in 183 Brazilian Caucasian individuals submitted to coronary angiography, of which 67 (37%) had normal coronary arteries (control group) and 116 (63%) had CAD (CAD patient group). The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, -1562 C/T MMP-9, -82 A/G MMP-12 polymorphisms were analyzed by PCR followed by restriction digestion. No significant differences were observed in allele frequencies between the CAD patients and controls. Haplotype analysis showed no differences between the CAD patients and controls. There was a significant difference in the severity of CAD, as assessed by the number of diseased vessels, in MMP-1 1G/1G homozygous individuals and in those homozygous for the 6A allele of the MMP-3 polymorphism. However, multivariate analysis showed that diabetes mellitus was the only variable independently associated with CAD severity. Our findings indicated that MMP polymorphisms have no significant impact on the risk and severity of CAD.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License