Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease:

Innate Immunity

HatemAlfakry¹ 

关键词: Aggregatibacter actinomycetemcomitans;    cardiovascular disease;    coronary artery disease;    gingival crevicular fluids;    hypochlorous acid;    lipopolysaccharide;    matrix metalloproteinases;    myeloperoxidase;    neutrophils;    oral infections;    periodontal diseases;    Porphyromonas gingivalis;    tissue inhibitor of matrix metalloproteinases;   

DOI  :  10.1177/1753425915617521

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Cardiovascular diseases are chronic inflammatory diseases that affect a large segment of society. Coronary heart disease (CHD), the most common cardiovascular disease, progresses over several years and affects millions of people worldwide. Chronic infections may contribute to the systemic inflammation and enhance the risk for CHD. Periodontitis is one of the most common chronic infections that affects up to 50% of the adult population. Under inflammatory conditions the activation of endogenous degradation pathways mediated by immune responses leads to the release of destructive cellular molecules from both resident and immigrant cells. Matrix metalloproteinases (MMPs) and their regulators can activate each other and play an important role in immune response via degrading extracellular matrix components and modulating cytokines and chemokines. The action of MMPs is required for immigrant cell recruitment at the site of inflammation. Stimulated neutrophils represent the major pathogen-fighting immune cells ...

【 授权许可】

CC BY