Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence

Genetics and Molecular Biology

Aline Lourenço Da Silva¹  Lucilene Arilho Ribeiro¹  Margaret E Cooper¹  Mary L Marazita¹  Danilo Moretti-ferreira¹ 

关键词: oral clefts;    cleft lip;    cleft palate;   

DOI  :  10.1590/S1415-47572006000300005

来源: SciELO

【 摘 要 】

Cleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P.

【 授权许可】

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