Equine protease inhibitor system as a marker for the diagnosis of chronic obstructive pulmonary disease (COPD)

Genetics and Molecular Biology

Myriam E. Vinocur²  Karin E. Brass²  Alexandre R. Caetano¹  Letícia F. Silva²  Aline C. Silva²  Carlos A.m. Silva² 

[1] ,Universidade Federal de Santa Maria Centro de Ciências Rurais Departamento de Clínica de Grandes AnimaisSanta Maria RS ,Brazil

关键词: horse;    chronic obstructive pulmonary disease;    protease inhibitor system;   

DOI  :  10.1590/S1415-47572005000300007

来源: SciELO

【 摘 要 】

The protease inhibitor system (PI) was investigated to ascertain if it can be used as a marker of chronic obstructive pulmonary disease (COPD) in thoroughbred horses. Serum samples were taken from healthy thoroughbreds (n = 13) and those diagnosed as having COPD (n = 24) or inflammatory airway disease (IAD, n = 38) as well as from 3,600 undiagnosed thoroughbred horses. PI allelic and genotypic frequencies were estimated using protein electrophoresis on starch and polyacrylamide gels. The four groups of horses showed high genotypic similarity and none of the observed alleles or genotypes of the equine PI system were found to be associated with COPD.

【 授权许可】

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