Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses

Genetics and Molecular Biology

Aline Correa Da Silva²  Karin Erica Brass²  Elgion Da Silva Loreto¹  Myriam Elizabeth Vinocur¹  Ricardo Pozzobon²  Marcos Da Silva Azevedo² 

[1] ,Universidade Federal de Santa Maria Departamento de Clínica de Grandes Animais Santa Maria RS ,Brazil

关键词: horse;    respiratory disease;    SSCP;    alpha-1-antitrypsin;    serpin;   

DOI  :  10.1590/S1415-47572011005000017

来源: SciELO

【 摘 要 】

The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.

【 授权许可】

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