A study of iga antibody response to different mycobacterium tuberculosis antigens in the diagnosis and monitoring of pulmonary tuberculosis

Brazilian Journal of Infectious Diseases

Janaina Miranda Bezerra²  Sandra Trevisan Beck¹  Kelly Aparecida Kanunfre¹  Olavo Munhoz Leite¹  Antônio Walter Ferreira¹ 

[1] ,Federal University of MaranhãoMaranhão MA

关键词: Tuberculosis;    IgA;    serological diagnosis;    ELISA;    glycolipid antigen;   

DOI  :  10.1590/S1413-86702009000100012

来源: SciELO

【 摘 要 】

We evaluated the performance of the ELISA technique in the detection of IgA antibodies against different Mycobacterium tuberculosis antigenic preparations in serum samples from 49 patients with pulmonary tuberculosis collected before and after the start of specific treatment. The controls consisted of serum samples from healthy patients without any prior contact with the bacteria and serum samples from patients with other pneumopathies. Glycolipid antigen gave the best diagnostic performance, with a sensitivity of 88% and specificities varying from 88 to 100% in the control groups. These antigens constitute a powerful tool for the diagnosis and monitoring of patients with pulmonary tuberculosis.

【 授权许可】

CC BY-NC-ND   
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