Cerebral aspergillosis presenting as a mass lesion

Brazilian Journal of Infectious Diseases

Negar Azarpira²  Majid Esfandiari²  Mohamad Hadi Bagheri¹  Sed Rakei¹  Soheila Salari¹ 

[1] ,Shiraz University of Medical Sciences Transplant Research Center Department of Pathology Shiraz ,Iran

关键词: Granulomatous inflammation;    Aspergillus fumigatus;    fungal infections;   

DOI  :  10.1590/S1413-86702008000400019

来源: SciELO

【 摘 要 】

Fungal infections of the central nervous system (CNS) are almost always a surprising finding. Their presentation is usually subtle, often without any diagnostic characteristics, and they are frequently mistaken for pyogenic abscesses, or brain tumors. Aspergillosis of the central nervous system is an uncommon infection, mainly occurring in immunocompromised patients. It may present in several forms, including meningitis, mycotic aneurysms, infarcts and a tumoral form. We report an intracranial granuloma due to Aspergillus fumigatus involving the anterior cranial fossa and the frontal lobe. The clinical symptoms began one year before admission. Final diagnosis was made after craniotomy. The patient was treated with an extensive excision of the cerebral mass and medical antifungal therapy (intravenous amphotericin B), but she failed to respond to these treatments and died.

【 授权许可】

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