Compositional changes of PBL population in patients with chronic hepatitis B virus infection

Brazilian Journal of Infectious Diseases

Khabiri Alireza¹  Abolhassani Mohsen¹  Aslani Sudabeh¹  Darabi Hiedeh¹  Bagheri Farideh¹  Alimohammadian Mohammad-hossein¹ 

[1] ,Pasteur Institute of Iran Department of Immunology Tehran,Iran

关键词: Hepatitis B virus;    chronic HBV infection;    HBsAg;    HBeAg;    HBeAb;    lymphocyte subset;    flow cytometry;   

DOI  :  10.1590/S1413-86702001000600009

来源: SciELO

【 摘 要 】

In this report we have analysed the peripheral blood lymphocyte of several patients with chronic hepatitis B virus infection with flow cytometry. Based on the presence and absence of the HBeAb, patients were divided into two groups. In both, all the patients were HBsAg positive with normal range of serum alanine aminotranferase (23.9 ± 17.8). We have found that the immunophenotypic profiles of patients were different from healthy donors with significant decrease in CD3+ T cells, specially CD8+ T cells and a siginificant increase in the CD19+ B cells. The differences were seen in other subset of T cells (CD4+) or NK cells (CD56+/CD16+ ) and HLA-DR markers were not significant. When the phenotypic profiles of both groups were compared with each other, such changes were more dominant in group II, with HBeAb positive than in group I, with HBeAb negative. Also, we have seen a correlation between the increase of CD19+ B cells and the decrease of CD3+ T cells. No such correlation was observed with other cells.

【 授权许可】

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