Severe Darier's disease in a psychiatric patient

Anais Brasileiros de Dermatologia

Jeane Jeong Hoon Yang¹  Roberta Simão Lopes¹  Medéia Carolina Fernandes Pereira¹  Antonio Jose Tebcherani¹  Mário Cezar Pires¹ 

关键词: Bipolar disorder;    Darier’s disease;    Genetic pleiotropy;    Mental disorders;   

DOI  :  10.1590/abd1806-4841.20153620

来源: SciELO

【 摘 要 】

Abstract Darier’s disease is characterized by dense keratotic lesions in the seborrheic areas of the body such as scalp, forehead, nasolabial folds, trunk and inguinal region. It is a rare genodermatosis, an autosomal dominant inherited disease that may be associated with neuropsichiatric disorders. It is caused by ATPA2 gene mutation, presenting cutaneous and dermatologic expressions. Psychiatric symptoms are depression, suicidal attempts, and bipolar affective disorder. We report a case of Darier’s disease in a 48-year-old female patient presenting severe cutaneous and psychiatric manifestations.

【 授权许可】

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