OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis

Anais Brasileiros de Dermatologia

Patrícia Luciana Batista Domingos²  Agostinho Gonçalves Viana²  Carlos Alberto De Carvalho Fraga²  Paulo Rogério Ferreti Bonan¹ 

[1] ,Universidade Estadual de Montes ClarosMontes Claros MG ,Brazil

关键词: Cytokines;    Immunohistochemistry;    Leishmaniasis;    Leishmaniasis cutaneous;    Citocinas;    Imunoistoquímica;    Leishmaniose;    Leishmaniose cutânea;   

DOI  :  10.1590/S0365-05962012000600005

来源: SciELO

【 摘 要 】

BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.

【 授权许可】

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