Lucio's phenomenon: another case reported in Brazil

Anais Brasileiros de Dermatologia

Rodrigo Monteiro²  Marcelo Guimarães Tiezzi¹  Marilda Aparecida Milanez Morgado De Abreu²  Claudia Cardoso Macedo De Oliveira²  Eduardo Vinícios Mendes Roncada²  Luciena Cegatto Martins Ortigosa² 

[1] ,Universidade do Oeste Paulista Hospital Regional de Presidente Prudente Dermatology ServicePresidente Prudente SP ,Brazil

关键词: Blood coagulation;    Blood coagulation disorders;    Drug therapy;    Erythema nodosum;    Leprosy;    lepromatous;    Therapeutics;    Thrombosis;    Coagulação sanguínea;    Eritema nodoso;    Hanseníase Virchowiana;    Quimioterapia;    Terapêutica;    Transtornos da coagulação sanguínea;    Trombose;   

DOI  :  10.1590/S0365-05962012000200017

来源: SciELO

【 摘 要 】

Lucio's phenomenon is defined as a variant of type 2 leprosy reaction. It is a rare event, occurring in the evolution of leprosy of Lucio and other forms of lepromatous leprosy. It has an exacerbated proliferation of Hansen bacilli in its pathophysiology, which invade blood vessel walls and injure endothelial cells, causing endothelial proliferation and decreasing the vascular lumen. This fact, associated with inflammatory reactions and changes in the coagulation system causes vascular thrombosis, ischemia, infarction and tissue necrosis, leading to the histopathological characteristic of the phenomenon. We report a case of lepromatous leprosy with irregular treatment that developed Lucio's phenomenon. Treatment with multidrug therapy, antibiotics, steroids and thalidomide achieved a favorable outcome.

【 授权许可】

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