Localized scleroderma: assessment of the therapeutic response to phototherapy

Anais Brasileiros de Dermatologia

Roberta Buense²  Ida Alzira Gomes Duarte¹  Marcio Bouer¹ 

[1] ,Irmandade da Santa Casa de Misericórdia de São PauloSão Paulo SP ,Brasil

关键词: PUVA therapy;    Phototherapy;    Scleroderma;    localized;    Ultrasonography;    Ultrasound;    high-intensity focused;    transrectal;    Esclerodermia localizada;    Fototerapia;    Terapia PUVA;    Ultrassom focalizado transretal de alta intensidade;    Ultrassonografia;   

DOI  :  10.1590/S0365-05962012000100007

来源: SciELO

【 摘 要 】

BACKGROUND: Scleroderma is a chronic autoimmune disease characterized by progressive connective tissue sclerosis and microcirculatory changes. Localized scleroderma is considered a limited disease. However, in some cases atrophic and deforming lesions may be observed that hinder the normal development. Literature reports indicate phototherapy as a therapeutic modality with favorable response in cutaneous forms of scleroderma. OBJECTIVES: This study had the purpose of assessing the phototherapy treatment for localized scleroderma. METHODS: Patients with localized scleroderma were selected for phototherapy treatment. They were classified according to the type of localized scleroderma and evolutive stage of the lesions. Clinical examination and skin ultrasound were used to demonstrate the results thus obtained. RESULTS: Some clinical improvement was observed after an average of 10 phototherapeutic sessions. All skin lesions were softer at clinical palpation with scores reduction upon pre and post treatment comparison. The ultrasound showed that most of the assessed lesions presented a decrease in dermal thickness, and only five maintained their previous measure. Treatment response was similar regardless of the type of phototherapeutic treatment employed. CONCLUSIONS: The proposed treatment was effective for all lesions, regardless of the phototherapeutic modality employed. The improvement was observed in all treated skin lesions and confirmed by clinical evaluation and skin ultrasound.

【 授权许可】

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