Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Revista da Associação Médica Brasileira

Carla Nogueira¹  Fernanda Borges¹  Edson Lameu¹  Carlos Franca¹  Cíntia Letícia Da Silva Rosa¹  Andréa Ramalho¹ 

关键词: vitamin A;    oxidative stress;    retinol;    β-carotene;    systemic inflammatory response syndrome;    vitamina A;    estresse oxidativo;    retinol;    β-caroteno;    SIRS;   

DOI  :  10.1590/1806-9282.61.02.116

来源: SciELO

【 摘 要 】

Objective: patients suffering systemic inflammatory response syndrome (SIRS) constitute a group susceptible to elevated levels of oxidative stress. This study’s aim is to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in these patients. Methods: forty-six patients were divided into 2 groups: those those without diet (G1; n=18) and those with enteral nutritional support (G2; n=28). Serum levels of retinol and total carotenoids were measured. C-reactive protein (CRP) levels and Apache scores were also calculated. Oxidative stress was estimated by measuring thiobarbituric acid reactive substance (TBARS) levels. Results: the patients’ median age was 66.9 (SD=19.3) years. Lower concentrations of retinol and carotenoids were found in 68.6 and 66.7% of G1, respectively. In G2, despite average vitamin A levels being 8078 + 4035, retinol and β-carotene were considered insufficient (31.2 and 33.4%, respectively). No difference was noted between the 2 groups, according to the variables studied, with the exception being PCR and β-carotene (p=0.002; p=0.01). Conclusion: the data presented in this study supports the need to establish/revise clinical practices in treating SIRS patients, in light of this micronutrient’s role in the immune system and antioxidant defense without it interfering with its toxicity.

【 授权许可】

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