Risk factors for micro and macrovascular disease in black and white patients with type 2 Diabetes mellitus

Revista da Associação Médica Brasileira

Caroline Kaercher Kramer²  Cristiane Bauermann Leitão¹  Lana Catani Pinto¹  Juliana Boza¹  Sandra Pinho Silveiro¹  Jorge Luiz Gross¹  Luis Henrique Canani¹ 

[1] ,Universidade Federal do Rio Grande do SulPorto Alegre RS

关键词: Diabetes mellitus;    Ethnicity;    Chronic complications;    Risk factors;    Diabetes mellitus;    Etnia;    Complicações crônicas;    Fatores de risco;   

DOI  :  10.1590/S0104-42302009000300024

来源: SciELO

【 摘 要 】

BACKGROUND: The prevalence of chronic complications in type 2 diabetes mellitus (DM) is higher in black patients. The reason for this finding is still unknown. The objective of this study was to analyze the micro and macrovascular risk factor profile of type 2 DM patients without advanced diabetic nephropathy according to ethnicity. METHODS: A cross-sectional multicentric regional study was conducted evaluating 780 patients. All patients were submitted to clinical and laboratory evaluation. Ethnicity was self-reported as white (n = 585) or black (n = 195). RESULTS: Black patients had lower triglycerides [115 (35-892) vs. 152 (34-1236) mg/dl; P <0.001] and higher HDL-cholesterol levels than whites (48.3 ± 13.5 vs. 44.8 ± 12.1 mg/dl; P = 0.002).White and black patients did not differ regarding fasting plasma glucose, A1c test, total and LDL cholesterol, blood pressure levels, insulin and HOMA-IR. There were no differences between groups regarding medication in use (statin: 18.5 vs. 19.3%, P = 1.000; fibrates: 1.5 vs. 0.7%, P = 0.680; angiotensin converting enzyme inhibitors: 39.5 vs. 43.8%, P = 0.375; acetylsalicylic acid: 29.9 vs. 27.7%, P = 0.673). CONCLUSIONS: There were no differences in the prevalence of the classic micro and macrovascular risk factors between ethnic groups. The study of non-conventional risk factors and genetic factors is essential to understand determinants of the worst outcomes presented by the African-Brazilian population.

【 授权许可】

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