Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial

Revista Latino-Americana de Enfermagem

Ana Luiza Soares Rodrigues¹  Beatriz Guitton Renaud Baptista De Oliveira¹  Débora Omena Futuro¹  Silvia Regina Secoli¹ 

关键词: Leg Ulcer;    Papain;    Carboxymethylcellulose Sodium;    Wound Healing;    Clinical Trial;    Nursing;    Úlcera da Perna;    Papaína;    Carboximetilcelulose Sódica;    Cicatrização;    Ensaio Clínico;    Enfermagem;    Úlcera de la Pierna;    Papaína;    Carboximetilcelulosa de Sodio;    Cicatrización de Heridas;    Ensayo Clínico;    Enfermería;   

DOI  :  10.1590/0104-1169.0381.2576

来源: SciELO

【 摘 要 】

OBJECTIVE: to assess the effectiveness of 2% papain gel compared to 2% carboxymethyl cellulose in the treatment of chronic venous ulcer patients.METHOD: randomized controlled clinical trial with 12-week follow-up. The sample consisted of 18 volunteers and 28 venous ulcers. In the trial group, 2% papain gel was used and, in the control group, 2% carboxymethyl cellulose gel.RESULTS: the trial group showed a significant reduction in the lesion area, especially between the fifth and twelfth week of treatment, with two healed ulcers and a considerable increase in the amount of epithelial tissue in the wound bed.CONCLUSION: 2% papain gel demonstrated greater effectiveness in the reduction of the lesion area, but was similar to 2% carboxymethyl cellulose gel regarding the reduction in the amount of exudate and devitalized tissue. Multicenter research is suggested to evidence the effectiveness of 2% papain gel in the healing of venous ulcers. UTN number: U1111-1157-2998

【 授权许可】

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