Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation

Revista Latino-Americana de Enfermagem

Rosimeire Barbosa Fonseca Guastaldi²  Silvia Regina Secoli¹ 

[1] ,Universidade Paulista SP ,Brazil

关键词: Drug Interactions;    Oncologic Nursing;    Nursing Assessment;    Interações de Medicamentos;    Enfermagem Oncológica;    Avaliação em Enfermagem;    Interacciones de Drogas;    Enfermería Oncológica;    Evaluación de Enfermería;   

DOI  :  10.1590/S0104-11692011000400015

来源: SciELO

【 摘 要 】

This study analyzed potential drug interactions (PDIs) of antimicrobials used in patients of hematopoietic stem cell transplantation and identified associated factors. The sample consisted of 70 patients admitted to a hospital in São Paulo. The PDIs were analyzed through the consultation of the Drug Interactions Facts and Drug Interactions Handbook. Descriptive statistics and logistic regression were used. Half of the sample was exposed to 13 PDIs, which occurred with fluconazole (53.8%), ciprofloxacin (30.8%) and sulfamethoxazole-trimethoprim (15.4%). Most (92.3%) were of moderate severity, with good evidence (61.6%), early delayed effect (61.5%) and need to have their therapy monitored (76.9%). Patients with four or more medications (p<0.001), aged between 40-49 years of age (p <0.001), and being male (p<0.001) were associated with PDIs. A PDI may result in adverse outcomes, impacting patients' morbidity and mortality. Combination regimens can be safe, provided there is careful monitoring by professionals involved in care delivery.

【 授权许可】

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