Hydroxyapatite-lignin composite as a metallic implant-bone tissue osseointegration improver: experimental study in dogs

Ciência Rural

Fabrício Luciani Valente¹  Letícia Corrêa Santos¹  Rodrigo Viana Sepúlveda¹  Gustavo Pereira Gonçalves¹  Renato Barros Eleotério¹  Emily Correna Carlo Reis¹  Andréa Pacheco Batista Borges¹ 

关键词: biomaterial;    biocompatibility;    osseointegration;    osteoconduction;    tissue regeneration;    biomaterial;    biocompatibilidade;    osseointegração;    osteocondução;    regeneração tecidual;   

DOI  :  10.1590/0103-8478cr20150110

来源: SciELO

【 摘 要 】

The study aimed to evaluate biocompatibility, osteoconduction and osseointegration of a pasty composite of hydroxyapatite (20%) and lignin (80%) as a promoter of metal implant and bone tissue integration. An intramedullary Schanz pin was implanted in both tibias of fifteen bitches. In the left tibia, the pin was coated with the biomaterial at the time of surgery. Marrow cavity was also filled with the biomaterial. Right limb did not receive the biomaterial, then constituting the control group. Tibias were harvested from five animals at 8, 60 and 150 days after surgery; three of them were analyzed by histological and biomechanical assessment and the two remaining tibias by X-ray diffraction. Results showed that the biomaterial is biocompatible, with osteoconductivity and osseointegration properties. Histological analysis and diffractograms showed the presence of hydroxyapatite in samples in all periods, although the presence of organic material of low crystallinity was variable. There was no statistical difference in the forces required for removal of the biocompatibility, osteoconductivity and osseointegration, it was not able to promote a better intramedullary pin anchorage.

【 授权许可】

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