Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Crystals

卷:11

Natalia S. Martynenko¹  Olga V. Rybalchenko¹  Diana Temralieva¹  Sergey Dobatkin¹  Aigul O. Kabiyeva²  Boris Straumal³  Yuri Estrin⁴  Almagul T. Mansharipova⁵  Maratbek T. Gabdullin⁶  Mikhail V. Kiselevskiy⁷  Natalia Yu. Anisimova⁷  Georgy Rybalchenko⁸ 

[1] A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, 119334 Moscow, Russia;

[2] Association of Early Career Doctors of Almaty, Almaty 050000, Kazakhstan;

[3] College of New Materials and Nanotechnologies, National University of Science and Technology “MISIS”, 119071 Moscow, Russia;

[4] Department of Materials Science and Engineering, Monash University, Clayton 3800, Australia;

[5] Faculty of General Medicine, College of New Materials and Nanotechnologies, Kazakh-Russian Medical University, Almaty 050000, Kazakhstan;

[6] Institute of Engineering and Information Technologies, Kazakh British Technical University, Almaty 050000, Kazakhstan;

[7] N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), 115478 Moscow, Russia;

[8] P.N. Lebedev Physical Institute of the RAS, 142432 Moscow, Russia;

关键词: magnesium alloy;    equal-channel angular pressing;    biodegradation;    biocompatibility;    alkaline phosphatase activity;    osteoconduction;   

DOI  :  10.3390/cryst11111381

来源: DOAJ

【 摘 要 】

Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.

【 授权许可】

Unknown