Cigarette smoke inhalation influences bone healing of post-extraction tooth socket: a histometric study in rats

Brazilian Dental Journal

Ana Paula Oliveira Giorgetti²  João Batista César Neto¹  Márcio Zaffalon Casati²  Enílson Antonio Sallum²  Francisco Humberto Nociti Júnior² 

[1] ,University of Campinas Piracicaba D ental School Periodontics DivisionPiracicaba SP ,Brazil

关键词: cigarette;    bone;    healing;    tooth socket;    rat;   

DOI  :  10.1590/S0103-64402012000300008

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate, histometrically, the bone healing of the molar extraction socket just after cigarette smoke inhalation (CSI). Forty male Wistar rats were randomly assigned to a test group (animals exposed to CSI, starting 3 days before teeth extraction and maintained until sacrifice; n=20) and a control group (animals never exposed to CSI; n=20). Second mandibular molars were bilaterally extracted and the animals (n=5/group/period) were sacrificed at 3, 7, 10 and 14 days after surgery. Digital images were analyzed according to the following histometric parameters: osteoid tissue (OT), remaining area (RA), mineralized tissue (MT) and non-mineralized tissue (NMT) in the molar socket. Intergroup analysis showed no significant differences at day 3 (p>0.05) for all parameters. On the 7th day, CSI affected negatively (p<0.05) bone formation with respect to NMT and RA (MT: 36%, NMT: 53%, RA: 12%; and MT: 39%, NMT: 29%, RA: 32%, for the control and test groups, respectively). In contrast, no statistically significant differences (p>0.05) were found at days 10 and 14. It may be concluded that CSI may affect socket healing from the early events involved in the healing process, which may be critical for the amount and quality of new-bone formation in smokers.

【 授权许可】

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