Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice

Brazilian Dental Journal

Ynara Bosco Oliveira Lima-arsati²  Carolina Castro Martins¹  Lília Alves Rocha¹  Jaime Aparecido Cury¹ 

[1] ,São Leopoldo Mandic School of Dentistry and Research CenterCampinas SP ,Brazil

关键词: fluoride;    water;    fluoridation;    dentifrice;    fingernail;    biomarkers;    fluorosis;   

DOI  :  10.1590/S0103-64402010000200001

来源: SciELO

【 摘 要 】

Fingernail has been suggested as a biomarker of fluoride (F) body burden, but there is no consensus if it would be a reliable indicator of F exposure from dentifrice. Therefore, the present study was conducted to investigate if fingernails would have sensitivity to detect F exposure from dentifrice in young children. Twenty-three 1-3-year-old children living in the city of Piracicaba (0.72 ppm F in water), Brazil, were enrolled in two phases of different F exposure: in phase A (1st to 11th week), they were exposed to the combination of F from diet (solids and liquids) and dentifrice (1,500 µg F/g as MFP), and in phase B (12th to 29th week), only to F from diet (the use of F dentifrice was interrupted). Fingernails were weekly clipped during 35 weeks for F determination. F intake from diet and dentifrice in each phase was also determined. Both analyses were made with ion-specific electrode. F intake (Mean ± SD) was significantly higher (p<0.01) when the children were exposed to F from diet+dentifrice than only to F from diet (0.086 ± 0.032 and 0.040 ± 0.009 mg F/day/kg body weight, respectively). However, F concentrations in nails collected during the whole experimental period of 35 weeks presented great variation with no trend of decreasing after F dentifrice intake interruption. The findings suggest that fingernail may not be a reliable F biomarker of body burden from dentifrice.

【 授权许可】

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