pH-cycling models to evaluate the effect of low fluoride dentifrice on enamel de- and remineralization

Brazilian Dental Journal

Celso Silva Queiroz²  Anderson Takeo Hara¹  Adriana Franco Paes Leme²  Jaime Aparecido Cury² 

[1] ,State University of Campinas School of Dentistry of Piracicaba Department of Physiological SciencesPiracicaba SP ,Brazil

关键词: demineralization;    remineralization;    fluoride;    dentifrice;   

DOI  :  10.1590/S0103-64402008000100004

来源: SciELO

【 摘 要 】

Since the currently available pH-cycling models do not differentiate the anti-caries potential of dentifrices with low fluoride (F) concentration, two models were developed and tested in the present. Bovine enamel blocks were subjected to the models and treated with F solutions containing from 70 to 280 mug F/mL in order to validate them in terms of dose-response effect. The models were also tested by evaluating the dentifrices Colgate Baby (500 mug F/g, as a low fluoride dentifrice), Tandy (1,100 mug F/g, as an active F-dentifrice) and Crest (1,100 mug F/g, as positive control). Enamel mineral loss or gain was assessed by surface and cross-sectional microhardness, and lesion depth was analyzed by polarized light microscopy. The pH-cycling models showed F dose-response effect either reducing enamel demineralization or enhancing remineralization. The low F dentifrice presented anti-caries potential, but it was not equivalent to the dentifrices containing 1,100 mug F/g. These data suggest that the models developed in this study were able to evaluate the anti-caries potential of low F dentifrice either on resistance to demineralization or on enhancement of remineralization.

【 授权许可】

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