Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats

Brazilian Dental Journal

Rodrigo Cardoso De Oliveira²  Renato Menezes²  Tânia Mary Cestari¹  Eulázio Mikio Taga¹  Rumio Taga¹  Marília Afonso Rabelo Buzalaf¹  José Mauro Granjeiro¹ 

[1] ,University of São Paulo Bauru Dental School Department of EndodonticsBauru SP ,Brazil

关键词: GTR;    barrier;    biomaterials;    absorbable membrane;   

DOI  :  10.1590/S0103-64402004000100001

来源: SciELO

【 摘 要 】

The treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process.

【 授权许可】

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