Exploring Light-Based Technology for Wound Healing and Appliance Disinfection

Journal of the Brazilian Chemical Society

Martha S. Ribeiro¹  Silvia Cristina Núñez¹  Caetano P. Sabino¹  Tania M. Yoshimura¹  Camila R. Silva¹  Gessé E. C. Nogueira¹  Hideo Suzuki¹  Aguinaldo S. Garcez¹ 

关键词: low-level light therapy;    methylene blue;    microbial reduction;    photodynamic therapy;    wound healing;   

DOI  :  10.5935/0103-5053.20150253

来源: SciELO

【 摘 要 】

Our goal was to build, characterize and test a red light-emitting diode (LED) device suitable for wound healing and disinfection of biomedical appliances. We designed and built a unique irradiator metallic box, for which irradiation distribution and spectral irradiance were calculated. In addition, we explored the device’s potential in photobiology comparing the healing of irradiated third degree burns with lesions that were left to heal spontaneously in mice. We also compared photodynamic microbial reduction with LED-irradiator and methylene blue vs. disinfection with a standard chemical solution, for photochemical applications. Our results showed that the LED-irradiator was able to accelerate the wound healing process compared to control group. In addition, a statistically significant microbial reduction was obtained with photodynamic inactivation compared to chemical decontamination. Thus, the prototype design is suitable for phototherapy studies since it is advantageous for low-level light therapy as well as for antimicrobial photodynamic therapy. In our perspective, this device can potentiate the dissemination of phototherapy studies to determine its suitable application in health sciences.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License