NS3 and NS5 proteins: important targets for anti-dengue drug design

Journal of the Brazilian Chemical Society

André S. De Oliveira²  Milene L. Da Silva¹  Ana Flávia C. S. Oliveira²  Cynthia C. Da Silva¹  Róbson R. Teixeira¹  Sérgio O. De Paula¹ 

[1] ,Federal Institute of Education, Science and Technology of Northern Minas GeraisAlmenara MG ,Brazil

关键词: dengue;    antivirus;    NS3 (non-structural 3);    NS5 (non-structural 5);    viral enzymes;   

DOI  :  10.5935/0103-5053.20140057

来源: SciELO

【 摘 要 】

Dengue is a neglected disease, one that is responsible for 22,000 deaths each year in areas where it is endemic. Despite the tremendous efforts invested in research for dengue treatments, no vaccine or antiviral has reached the market, and disease treatment is limited to supportive care. Among strategies that have been used in the search for and development of an antiviral against dengue, the inhibition of viral enzymes has been proven to be the most successful approach. This review covers the major progresses that have been published concerning compounds that inhibit viral enzymes.

【 授权许可】

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