Microwave-assisted synthesis of N-heterocycles and their evaluation using an acetylcholinesterase immobilized capillary reactor

Journal of the Brazilian Chemical Society

Diego P. Sangi¹  Julia L. Monteiro¹  Kenia L. Vanzolini¹  Quezia B. Cass¹  Marcio W. Paixão¹  Arlene G. Corrêa¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brazil

关键词: dithioketals;    oxazolidines;    imidazolidines;    benzoxazoles;    microwaves;    green technology;   

DOI  :  10.5935/0103-5053.20140056

来源: SciELO

【 摘 要 】

Polarized ketene dithioketals have been recognized as useful building blocks in many synthetic operations. In this work, a transition-metal-free annulations of 1,1-bis(thiomethyl)-2-nitroethylene with hydroxylalkylamines or alkyldiamines have been reported. This methodology provides a directed approach to N-heterocycles, e.g., imidazolidines, oxazolidines and benzoxazoles under microwave conditions. These compounds were evaluated as acetylcholinesterase inhibitors by using an enzyme immobilized capillary reactor-tandem mass spectrometry.

【 授权许可】

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