Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

Molecules

José Alixandre De Sousa Luis¹  José Maria Barbosa Filho¹  Bruno Freitas Lira¹  Isac Almeida Medeiros¹  Liana Clébia Soares Lima de Morais¹  Alexsandro Fernandes Dos Santos¹  Cledualdo Soares de Oliveira¹ 

[1] ¹Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa - PB, CEP 58.051-970, Brazil ²Centro de Educação e Saúde, Unidade Acadêmica de Saúde, Universidade Federal de Campina Grande, Cuité - PB, CEP 58.175-000, Brazil ³Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa - PB, CEP 58059-900, Brazil

关键词: hydantoins;    C-phenylglycine;    imidazolidines;    2-thioxoimidazolidine-4-ones;   

DOI  :  10.3390/molecules15010128

来源: mdpi

【 摘 要 】

Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70–74%. The mass, infrared, ¹H and ¹³C-NMR spectra of representative products are discussed.

【 授权许可】

CC BY   
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