Synthesis, crystal structure and biological activity of novel diester cyclophanes

Journal of the Brazilian Chemical Society

Pengfei Zhang¹  Bingqin Yang¹  Xianwen Fang¹  Zhao Cheng¹  Meipan Yang¹ 

[1] ,Northwest University Key Laboratory of Synthetic and Natural Functional Molecule Chemistry Department of ChemistryXi'an Shaanxi ,P. R. China

关键词: synthesis;    ester cyclophanes;    crystal;    antibacterial activity;    antifungal activity;   

DOI  :  10.1590/S0103-50532012005000045

来源: SciELO

【 摘 要 】

A series of novel diester cyclophanes was synthesized by esterification of 1,2-benzenedicarbonyl chloride with eight different diols under high dilution conditions. The structures of the compounds were verified by elemental analysis, ¹H nuclear magnetic resonance (NMR), IR spectroscopy and high resolution mass spectrometry (HRMS). The crystal structures of two compounds were characterized by single crystal X-ray diffractometry (XRD). All the new cyclophanes were evaluated for biological activities and the results showed that some of these compounds have low antibacterial or antifungal activities.

【 授权许可】

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