O-iodoxybenzoic acid in water: optimized green alternative for multicomponent one-pot synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines

Journal of the Brazilian Chemical Society

Santosh Takale²  Jaidas Patil²  Vikas Padalkar¹  Rajaram Pisal¹  Atul Chaskar¹ 

[1] ,Changu Kana Thakur Research CentreNavi Mumbai,India

关键词: O-iodoxybenzoic acid;    green catalyst;    thiopyridines;    aqueous media;    multicomponent reactions;   

DOI  :  10.1590/S0103-50532012000500024

来源: SciELO

【 摘 要 】

A multicomponent one-pot reaction of aromatic aldehyde, malononitrile and thiophenol in the presence of iodoxybenzoic acid (IBX) in aqueous media furnished 2-amino-3,5-dicarbonitrile-6-thiopyridine in good to excellent yield. Eventually, a catalyst could be easily recovered and reused without loss of its catalytic property.

【 授权许可】

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