O-iodoxybenzoic acid in water: optimized green alternative for multicomponent one-pot synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines

Journal of the Brazilian Chemical Society

National Taiwan University, Taipei, Taiwan¹  Pisal, Rajaram¹  Patil, Jaidas¹  Chaskar, Atul¹  Institute of Chemical Technology, Mumbai, India¹  Takale, Santosh¹  Changu Kana Thakur Research Centre, Navi Mumbai, India¹  Padalkar, Vikas¹ 

关键词: O-iodoxybenzoic acid;    green catalyst;    thiopyridines;    aqueous media;    multicomponent reactions;   

DOI  :  10.1590/S0103-50532012000500024

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A multicomponent one-pot reaction of aromatic aldehyde, malononitrile and thiophenol in the presence of iodoxybenzoic acid (IBX) in aqueous media furnished 2-amino-3,5-dicarbonitrile-6-thiopyridine in good to excellent yield. Eventually, a catalyst could be easily recovered and reused without loss of its catalytic property.

【 授权许可】

Unknown