Fatty acid synthase inhibitors isolated from Punica granatum L.

Journal of the Brazilian Chemical Society

He-zhong Jiang²  Qing-yun Ma²  Hui-jin Fan¹  Wen-juan Liang²  Sheng-zhuo Huang²  Hao-fu Dai²  Peng-cheng Wang²  Xiao-feng Ma¹  You-xing Zhao² 

[1] ,Chinese Academy of Tropical Agricultural Sciences Institute of Tropical Bioscience and Biotechnology Haikou,People's Republic of China

关键词: fatty acid synthase (FAS);    Punica granatum;    flavogallonic acid;    punicaone;   

DOI  :  10.1590/S0103-50532012000500014

来源: SciELO

【 摘 要 】

The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 µmol L-1.

【 授权许可】

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