Fatty acid synthase inhibitors isolated from Punica granatum L.

Journal of the Brazilian Chemical Society

Dai, Hao-Fu¹  Fan, Hui-Jin¹  Jiang, He-Zhong¹  Huang, Sheng-Zhuo¹  Liang, Wen-Juan¹  Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China¹  Ma, Xiao-Feng¹  Wang, Peng-Cheng¹  Ma, Qing-Yun¹  Zhao, You-Xing¹  Southwest Jiaotong University, Chengdu, People's Republic of China¹  Graduate University of Chinese Academy of Sciences, Beijing, People's Republic of China¹ 

关键词: fatty acid synthase (FAS);    Punica granatum;    flavogallonic acid;    punicaone;   

DOI  :  10.1590/S0103-50532012000500014

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 µmol L-1.

【 授权许可】

Unknown