Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm

Journal of the Brazilian Chemical Society

Kato Lucilia²  Cecília M. A. De Oliveira²  Emiret O. Faria²  Laryssa C. Ribeiro²  Brenda G. Carvalho²  Cleuza C. Da Silva¹  Ivânia T. A. Schuquel¹  Silvana M. O. Santin¹  Celso V. Nakamura¹  Elisandra A. Britta¹  Nathielle Miranda¹  Amadeu H. Iglesias¹  Piero G. Delprete¹ 

[1] ,Universidade Federal de Goiás Instituto de Química Goiânia GO ,Brazil

关键词: β-carboline alkaloids;    antiprotozoal;    Trypanosoma;    Leishmania;    Psychotria prunifolia;    Rubiaceae;   

DOI  :  10.1590/S0103-50532012000200024

来源: SciELO

【 摘 要 】

The continuity of the phytochemical study of crude extracts of P. prunifolia's roots and branches led to the isolation of five indole-β-carboline alkaloids. Among them, the 10-hydroxy-iso-deppeaninol and N-oxide-10-hydroxy-antirhine derivatives are described here for the first time. The structures were achieved through 1D and 2D NMR, IR and HRMS analyses. The branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide showed selective activity against L. amazonensis, with IC50 values of 16.0 and 40.7 µg per mL, respectively.

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