Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm

Journal of the Brazilian Chemical Society

Oliveira, Cecília M. A. de¹  Lucilia, Kato¹  Universidade Estadual de Maringá, Maringá, Brazil¹  Nakamura, Celso V.¹  Silva, Cleuza C. da¹  Britta, Elisandra A.¹  Iglesias, Amadeu H.¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Santin, Silvana M. O.¹  Waters Technologies do Brasil LTDA, Barueri, Brazil¹  Delprete, Piero G.¹  Miranda, Nathielle¹  Ribeiro, Laryssa C.¹  Herbier de Guyane, Cayenne Cedex, France¹  Schuquel, Ivânia T. A.¹  Carvalho, Brenda G.¹  Faria, Emiret O.¹ 

关键词: β-carboline alkaloids;    antiprotozoal;    Trypanosoma;    Leishmania;    Psychotria prunifolia;    Rubiaceae;   

DOI  :  10.1590/S0103-50532012000200024

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The continuity of the phytochemical study of crude extracts of P. prunifolia's roots and branches led to the isolation of five indole-β-carboline alkaloids. Among them, the 10-hydroxy-iso-deppeaninol and N-oxide-10-hydroxy-antirhine derivatives are described here for the first time. The structures were achieved through 1D and 2D NMR, IR and HRMS analyses. The branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide showed selective activity against L. amazonensis, with IC50 values of 16.0 and 40.7 µg per mL, respectively.

【 授权许可】

Unknown