Journal of the Brazilian Chemical Society | |
Polar compounds isolated from the leaves of Calea prunifolia H.B.K. and their anti-adrenergic related vasodilator activity | |
Pilar Puebla2  Nataly Aranguren1  Javier Rincón1  Maritza Rojas1  Mario Guerrero1  Arturo San Feliciano2  | |
[1] ,Salamanca University Faculty of Pharmacy Laboratory of Organic and Pharmaceutical ChemistrySalamanca,Spain | |
关键词: Calea prunifolia; kaurane diterpenoid glycoside; antiadrenegic activity; antihypertensive agents; | |
DOI : 10.1590/S0103-50532011001200007 | |
来源: SciELO | |
【 摘 要 】
The leaves of Calea prunifolia H.B.K., medicinal specie used in Colombian folk medicine for hypertension have been analysed for their chemical constituents, resulting in the isolation of one flavonoid glycoside, one quinic acid derivative and one kaurane diterpenoid glycoside. Their chemical structures were elucidated on the basis of spectral analysis, including HRMS, 1D- and 2D-NMR data. The vasodilator effect related to anti adrenergic activity of the three compounds was evaluated in isolated aortic rings from Wistar rats contracted cumulatively with phenylephrine (from 1× 10-9 to 5 × 10-5 mol L-1). Although these compounds were devoid of significant vasodilator activity when they were tested alone (1 µg mL-1), mixtures of them (1:1:1) and the own EtOH extract exerted preventive anti-adrenergic activity increasing the phenylephrine CE50 from 2.3 × 10-8 to 1.3 × 10-7 and 8.0 × 10-7 mol L-1, respectively.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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