Polar compounds isolated from the leaves of Calea prunifolia H.B.K. and their anti-adrenergic related vasodilator activity

Journal of the Brazilian Chemical Society

Salamanca University, Salamanca, Spain¹  Puebla, Pilar¹  Aranguren, Nataly¹  Rojas, Maritza¹  National University of Colombia, Bogotá, Colombia¹  Rincón, Javier¹  Feliciano, Arturo San¹  Guerrero, Mario¹ 

关键词: Calea prunifolia;    kaurane diterpenoid glycoside;    antiadrenegic activity;    antihypertensive agents;   

DOI  :  10.1590/S0103-50532011001200007

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The leaves of Calea prunifolia H.B.K., medicinal specie used in Colombian folk medicine for hypertension have been analysed for their chemical constituents, resulting in the isolation of one flavonoid glycoside, one quinic acid derivative and one kaurane diterpenoid glycoside. Their chemical structures were elucidated on the basis of spectral analysis, including HRMS, 1D- and 2D-NMR data. The vasodilator effect related to anti adrenergic activity of the three compounds was evaluated in isolated aortic rings from Wistar rats contracted cumulatively with phenylephrine (from 1× 10-9 to 5 × 10-5 mol L-1). Although these compounds were devoid of significant vasodilator activity when they were tested alone (1 µg mL-1), mixtures of them (1:1:1) and the own EtOH extract exerted preventive anti-adrenergic activity increasing the phenylephrine CE50 from 2.3 × 10-8 to 1.3 × 10-7 and 8.0 × 10-7 mol L-1, respectively.

【 授权许可】

Unknown