A "green" synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities

Journal of the Brazilian Chemical Society

Lingam Venkata Reddy²  Suresh Babu Nallapati¹  Syed Sultan Beevi¹  Lakshmi Narasu Mangamoori¹  Khagga Mukkanti²  Sarbani Pal¹ 

[1] ,JNT University Institute for Sciences and Technology Center for Chemical Sciences and Technology and Center for BiotechnologyHyderabad,India

关键词: 2-chloroquinoline-3-carboxaldehyde;    acylhydrazone;    PEG 400;    cytotoxicity;   

DOI  :  10.1590/S0103-50532011000900017

来源: SciELO

【 摘 要 】

We report some hybrid molecules based on N-(quinoline-3-ylmethylene)benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in PEG 400. The "green" solvent PEG 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. Some of the compounds synthesized showed significant cytotoxic activity when tested in vitro

【 授权许可】

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