A "green" synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities

Journal of the Brazilian Chemical Society

Mangamoori, Lakshmi Narasu¹  Pal, Sarbani¹  JNT University, Hyderabad, India¹  Mukkanti, Khagga¹  Nallapati, Suresh Babu¹  Reddy, Lingam Venkata¹  Beevi, Syed Sultan¹  MNR Degree and PG College, Hyderabad, India¹ 

关键词: 2-chloroquinoline-3-carboxaldehyde;    acylhydrazone;    PEG 400;    cytotoxicity;   

DOI  :  10.1590/S0103-50532011000900017

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

We report some hybrid molecules based on N-(quinoline-3-ylmethylene)benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in PEG 400. The "green" solvent PEG 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. Some of the compounds synthesized showed significant cytotoxic activity when tested in vitro.

【 授权许可】

Unknown