Metabolites from roots of Colubrina greggii var. yucatanensis and evaluation of their antiprotozoan, cytotoxic and antiproliferative activities

Journal of the Brazilian Chemical Society

Dafne B Domínguez-carmona²  Fabiola Escalante-erosa²  Karlina García-sosa²  Grace Ruiz-pinell¹  David Gutierrez-yapu¹  Manuel J Chan-bacab¹  Rosa E Moo-puc¹  Nigel C Veitch¹  Alberto Giménez-turba¹  Luis M Peña-rodríguez² 

[1] ,Centro de Investigación Científica de Yucatán Unidad de Biotecnología Mérida Yucatán ,México

关键词: Colubrina greggii var. yucatanensis;    Rhamnaceae;    antiprotozoan;    cytotoxic ceanothane;   

DOI  :  10.1590/S0103-50532011000700013

来源: SciELO

【 摘 要 】

Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.

【 授权许可】

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