Metabolites from roots of Colubrina greggii var. yucatanensis and evaluation of their antiprotozoan, cytotoxic and antiproliferative activities

Journal of the Brazilian Chemical Society

Universidad Mayor de San Andrés, La Paz, Bolivia¹  Escalante-Erosa, Fabiola¹  Royal Botanic Gardens Kew, Richmond, UK¹  Universidad Autónoma de Campeche, Campeche, México¹  Gutierrez-Yapu, David¹  Moo-Puc, Rosa E¹  Ruiz-Pinell, Grace¹  García-Sosa, Karlina¹  Peña-Rodríguez, Luis M¹  Veitch, Nigel C¹  Centro de Investigación Científica de Yucatán, Mérida, México¹  IMSS, Mérida, México¹  Giménez-Turba, Alberto¹  Domínguez-Carmona, Dafne B¹  Chan-Bacab, Manuel J¹ 

关键词: Colubrina greggii var. yucatanensis;    Rhamnaceae;    antiprotozoan;    cytotoxic ceanothane;   

DOI  :  10.1590/S0103-50532011000700013

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.

【 授权许可】

Unknown