Metal halide hydrates as lewis acid catalysts for the conjugated friedel-crafts reactions of indoles and activated olefins

Journal of the Brazilian Chemical Society

Cristiane S. Schwalm¹  Marco Antonio Ceschi¹  Dennis Russowsky¹ 

[1] ,Universidade Federal do Rio Grande do Sul Instituto de Química Porto Alegre RS ,Brazil

关键词: Friedel-Crafts;    indoles;    activated olefins;    metal halide hydrates;    Lewis acids;    Michael addition;   

DOI  :  10.1590/S0103-50532011000400003

来源: SciELO

【 摘 要 】

Metal halide hydrates such as SnCl2·2H2O, MnCl2·4H2O, SrCl2·6H2O, CrCl2·6H2O, CoCl2·6H2O e CeCl3·7H2O were investigated as mild Lewis acids catalysts for the conjugate Friedel-Crafts reaction between indoles and activated olefins. The reactions were carried out with aliphatic unsaturated ketones over a period of days at room temperature, while chalcones reacted only under reflux conditions. The reactions with nitrostyrenes were either performed in solvent or under solventless conditions. In all cases reasonable to good yields were obtained.

【 授权许可】

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