Microwave-assisted Passerini reactions under solvent-free conditions

Journal of the Brazilian Chemical Society

Angélica De Fátima S Barreto¹  Otilie E Vercillo¹  Carlos Kleber Z Andrade¹ 

关键词: α-acyloxy carboxyamides;    Passerini reaction;    microwave irradiation;    solvent-free reactions;   

DOI  :  10.1590/S0103-50532011000300008

来源: SciELO

【 摘 要 】

Various α-acyloxy carboxyamides were easily obtained combining three building blocks in one step: a carboxylic acid, an aldehyde and an isonitrile (Passerini reaction), using microwave irradiation under solvent-free conditions. The products were obtained in good yields (61-90%) and in short reaction times (< 5 min), using two different temperatures (60 and 120 ºC). At 120 ºC, the yields were higher and the reactions faster (< 1 min). Most of the obtained products are multifunctional allowing their application in consecutive Passerini reactions

【 授权许可】

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