Genetic toxicity of three symmetrical diselenides in yeast

Journal of the Brazilian Chemical Society

Renato M Rosa²  Temenouga N Guecheva¹  Iuri M. De Oliveira¹  Antônio L Braga¹  João A. P Henriques¹ 

[1] ,Universidade Luterana do Brasil Laboratório de Genética Toxicológica Canoas RS ,Brazil

关键词: organoselenium;    diphenyl diselenide;    Saccharomyces cerevisiae;   

DOI  :  10.1590/S0103-50532010001100013

来源: SciELO

【 摘 要 】

Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.

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