Genetic toxicity of three symmetrical diselenides in yeast

Journal of the Brazilian Chemical Society

Braga, Antônio L¹  Oliveira, Iuri M. de¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil¹  Universidade Luterana do Brasil, Canoas, Brazil¹  Rosa, Renato M¹  Guecheva, Temenouga N¹  Universidade de Caxias do Sul, Caxias do Sul, Brazil¹  Universidade Federal de Santa Catarina, Florianópolis, Brazil¹  Henriques, João A. P¹ 

关键词: organoselenium;    diphenyl diselenide;    Saccharomyces cerevisiae;   

DOI  :  10.1590/S0103-50532010001100013

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.

【 授权许可】

Unknown