Journal of the Brazilian Chemical Society | |
Genetic toxicity of three symmetrical diselenides in yeast | |
Braga, Antônio L1  Oliveira, Iuri M. de1  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil1  Universidade Luterana do Brasil, Canoas, Brazil1  Rosa, Renato M1  Guecheva, Temenouga N1  Universidade de Caxias do Sul, Caxias do Sul, Brazil1  Universidade Federal de Santa Catarina, Florianópolis, Brazil1  Henriques, João A. P1  | |
关键词: organoselenium; diphenyl diselenide; Saccharomyces cerevisiae; | |
DOI : 10.1590/S0103-50532010001100013 | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050580879ZK.pdf | 174KB | download |