Determination and validation of nimesulide in pharmaceutical formulation by near infrared spectroscopy

Journal of the Brazilian Chemical Society

Werickson F. C. Rocha²  André Luis Rosa¹  José Antônio Martins¹  Ronei Jesus Poppi² 

[1] ,University of Campinas Institute of Chemistry Campinas SP ,Brazil

关键词: near-infrared spectroscopy;    nimesulide;    figures of merit;    net analyte signal;   

DOI  :  10.1590/S0103-50532010001000019

来源: SciELO

【 摘 要 】

The determination of nimesulide in pharmaceutical formulation in the range of 10.38 to 39.47% m/m using near infrared spectroscopy and multivariate calibration based on partial least squares (PLS) and net analyte signal (NAS) was studied and validated by establishing its figures of merit. Suitable results were obtained, with limit of detection of 0.61%, limit quantification of 2.03%, accuracy estimated as root mean square error of prediction (RMSEP) of 1.05%, mean selectivity of 0.006, sensitivity of 0.004%, inverse analytical sensitivity of (0.20%)-1 and signal-to-noise ratio of 181. In addition, it was obtained relative errors lower than 10% that are acceptable values for quality control of this drug. These results indicate that the proposed method can be used in pharmaceutical industries as an alternative to standard analytical procedures.

【 授权许可】

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