Chemical composition and anti-inflammatory evaluation of essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae)

Journal of the Brazilian Chemical Society

João Henrique G Lago²  Larissa A. C Carvalho¹  Flávia S. Da Silva¹  Daniela De O Toyama¹  Oriana A Fávero¹  Paulete Romoff¹ 

[1] ,Universidade Federal de São Paulo Departamento de Ciências Exatas e da Terra Diadema SP ,Brazil

关键词: Drimys brasiliensis Miers;    essential oil composition;    antinociceptive;    anti-inflammatory;    acute toxicity;   

DOI  :  10.1590/S0103-50532010000900024

来源: SciELO

【 摘 要 】

The essential oils from leaves and stem barks from Drimys brasiliensis Miers (Winteraceae) were individually obtained by hydrodistillation and their compounds characterized by use of GC/FID and GC/MS. The main identified derivatives were monoterpenes (leaves 4.31% and stem barks 90.02%) and sesquiterpenes (leaves 52.31% and stem barks 6.35%). Additionally, the sesquiterpene polygodial was isolated from hexane extract from stem barks of D. brasiliensis after chromatographic steps and characterized by spectroscopic means, mainly NMR. Aiming the evaluation of anti-inflammatory potential, the crude essential oils and the sesquiterpene polygodial were subjected to bioassays to evaluate the acute toxicity of these compounds as well as the anti-inflammatory and antinociceptive activities induced by carrageenan and formalin in mices. Ours results showed that essential oil obtained from the stem barks significantly reduced the oedema induced by carrageenan. The anti-inflammatory effect induced by stem barks oil (at 200 mg kg-1) was similar to observed for indomethacin (at 10 mg kg-1) and superior for polygodial (at 200 mg kg-1) in 30 and 60 min after the administration of essential oils. The inflammatory response induced by formalin was effective to the stem barks oil (62.5%) in comparison to polygodial (50.0%).

【 授权许可】

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