Antinociceptive Effect of Hydantoin 3-Phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in Mice

Molecules

Ronaldo Bezerra de Queiroz²  Fabíola Lélis de Carvalho²  Diogo Vilar da Fons²  José Maria Barbosa-Filho²  Paula Regina Rodrigues Salgado²  Luciano Leite Paulo²  Ana Bárbara Maroja de Queiroz²  Liana Clປiade Morais Pordeus²  Severino Araújo de Souza¹  Helivaldo Diogenes da Silva Souza¹  Bruno Freitas Lira¹  Petrônio Filgueiras de Athayde-Filho¹ 

[1] Department of Chemistry, Federal University of Paraiba, João Pessoa PB 58059-900, Brazil; E-Mails:;Center for Health Sciences, Federal University of Paraiba, João Pessoa PB 58059-900, Brazil; E-Mails:

关键词: hydantoin;    psychopharmacology;    antinociceptive;    anti-inflammatory;   

DOI  :  10.3390/molecules20010974

来源: mdpi

【 摘 要 】

Imidazolidine derivatives, or hydantoins, are synthetic compounds with different therapeutic applications. Many imidazolidine derivatives have psychopharmacological properties, such as phenytoin, famous for its anticonvulsant efficacy, but also effective in the treatment of neuropathic pain. The hydantoin, 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione (IM-3), synthesized from the amino acid, glycine, was selected for psychopharmacological studies in mice on the basis of its chemical and structural similarity with phenytoin. The first step of this study was to define the LD₅₀, which determined the doses of 50, 100 and 200 mg/kg for subsequent tests. The results obtained from the behavioral screening indicated that IM-3 produces decreased ambulation and analgesia in mice. Motor coordination and anxiety behavior were not affected by treatment with IM-3, as observed in the rotarod and elevated plus-maze tests, respectively. Regarding its antinociceptive properties, IM-3 showed efficacy in the acetic acid-induced writhing test by increasing the latency of the first writhe and reducing the number of writhes, as well as reducing the paw licking time in the second phase of the formalin test. The behavior of treated animals exposed to the hot plate test, however, did not differ from that of the control group. These data suggest that IM-3 has antinociceptive effects in mice, which is probably mediated by anti-inflammatory mechanisms.

【 授权许可】

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