An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis

Journal of the Brazilian Chemical Society

Luiz A. Basso²  Cristopher Z. Schneider²  Anderson J. A. B. Dos Santos²  André A. Dos Santos Jr¹  Maria M. Campos¹  André A. Souto²  Diógenes S. Santos² 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul Centro de Pesquisas em Biologia Molecular e Funcional Porto Alegre RS ,Brazil

关键词: Mycobacterium tuberculosis;    enoyl reductase;    toxicology;    large-scale synthesis;    metallodrug;   

DOI  :  10.1590/S0103-50532010000700026

来源: SciELO

【 摘 要 】

Here we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, its oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a promising chemotherapeutic agent aiming at the inhibition of a validated and druggable molecular target.

【 授权许可】

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