An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis

Journal of the Brazilian Chemical Society

Campos, Maria M.¹  Basso, Luiz A.¹  Santos Jr, André A. dos¹  Souto, André A.¹  Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil¹  Schneider, Cristopher Z.¹  Santos, Anderson J. A. B. dos¹  Santos, Diógenes S.¹ 

关键词: Mycobacterium tuberculosis;    enoyl reductase;    toxicology;    large-scale synthesis;    metallodrug;   

DOI  :  10.1590/S0103-50532010000700026

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Here we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, its oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a promising chemotherapeutic agent aiming at the inhibition of a validated and druggable molecular target.

【 授权许可】

Unknown