Simple method for fast deprotection of nucleosides by triethylamine-catalyzed methanolysis of acetates in aqueous medium

Journal of the Brazilian Chemical Society

Lidiane Meier¹  Gustavo C. Monteiro¹  Rodrigo A. M. Baldissera¹  Marcus Mandolesi Sá¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Química Florianópolis SC ,Brazil

关键词: nucleosides;    triethylamine-catalyzed transesterification;    microwave-assisted synthesis;    deacetylation;   

DOI  :  10.1590/S0103-50532010000500013

来源: SciELO

【 摘 要 】

A straightforward methodology for deacetylation of protected ribonucleosides was developed based on triethylamine-catalyzed solvolysis in aqueous methanol. Reactions are completed in a few minutes under microwave irradiation and the free nucleosides are obtained in high yield after simple evaporation of volatiles. Other important features include the involvement of readily available reagents and the compatibility with diverse functional groups, which make this process very attractive for broad application.

【 授权许可】

CC BY   
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